Semi-determination of Urinary Hippuric Acid as a Screening Test on Persons Exposed to Toluene Vapors

Significance of urinary hippuric acid determination as an index of toluene exposure.

Urinary hippuric acid concentration after occupational exposure to toluene.

The results of industrial investigations have shown a correlation between the rate of hippuric acid excretion in a single urine sample collected after daily occupational exposure and the amount of toluene absorbed. The rate of hippuric acid excretion and the average concentration of toluene vapour during exposure time were also related. The quantitative range of the test has been limited to amo...

Toxicokinetics of toluene and urinary excretion of hippuric acid after human exposure to 2H8-toluene.

Nine male volunteers were exposed to 2H8-toluene (200 mg/m3 for two hours during a workload of 50 W) via inspiratory air with the aid of a breathing valve and mouthpiece. Labelled toluene was used to differentiate between hippuric acid originating from exposure to toluene and hippuric acid normally excreted in urine. The total uptake of toluene was 2.2 (standard deviation (SD) 0.2) mmol, or 50%...

Urinary excretion of hippuric acid and m- or p-methylhippuric acid in the urine of persons exposed to vapours of toluene and m- or p-xylene as a test of exposure.

Ogata, M., Tomokuni, K., and Takatsuka, Y. (1970). Brit. J. industr. Med., 27,43-50. Urinary excretion of hippuric acid and mor p-methylhippuric acid in the urine of persons exposed to vapours of toluene and mor p-xylene as a test of exposure. Twenty-three male volunteers were exposed in groups of four or five to toluene and mand p-xylene vapour for periods of 3 hours or of 7 hours with one bre...

efficacy of urinary hippuric acid as a biomarker of low level exposure to toluene in petroleum depot workers

exposure to toluene can be associate with genotoxicity, neurological dysfunction, reproductive toxicity, and etc. biomonitoring of hippuric acid (ha) is used for a long time as an occupational exposure index to toluene. the aim of this study was to explore efficiency of ha as a biomarker of exposure to low level of toluene for iranian petroleum depot workers in 2011. personal monitoring to tolu...